Case Presentation - Fall, 2005

NOTE: The diagnosis and analysis for this case study were provided by an independent physician. All conclusions and opinions are those of the physician and not Hologic, Inc.

History: 77 year old, female

LMP: Menopause

Case provided by: Thomas Meier, SCT(ASCP), of Pathology Consultants of New Mexico

Cytologic Diagnosis: Satifactory for evaluation; endocervical/transformation zone cells are present; atypical glandular cells, favor neoplastic.

Histologic Diagnosis: A cervical biopsy was negative for malignancy, but the endocervical curettage and endometrial biopsy showed adenocarcinoma.

The ThinPrep Imaging System images the entire ThinPrep specimen cell spot, selecting 22 fields of interest for every slide for review by a cytotechnologist using the Autolocate mode of the system's automated Review Scope. If abnormal cells are present in any field of view the cytotechnologist screens the entire specimen cell spot, using the Autoscan mode of the Review Scope. At the conclusion of the slide review electronically marked areas are ink marked by the Review Scope marker for review by a pathologist. The x and y coordinates representing marked locations are stored in the System's computer server along with the original 22 fields of interest detected by the Imager.

A multi-center trial to evaluate the screening capability of the Imager resulted in increased sensitivity for ASC-US and higher diagnoses compared to manual review of ThinPrep slides. In addition to increased sensitivity, the cytotechnologist was able to screen more slides in an eight hour workday, allowing for a potential increase in productivity.

Results from a study of cancer cases reviewed by cytotechnologists and cytopathologists showed that the Imager successfully identified abnormalities in its 22 fields of view that prompted a full review of the slide. This case supports the results of that study when the system is used in a clinical setting.

  1. ThinPrepT Imaging System Review Scope Operator's Manual; ThinPrep® Imaging System Operation Summary and Clinical Information; Hologic, Inc., 2004.