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Cytology of Pleural, Pericardial and Peritoneal Cavity Effusions

EFFUSIONS AND WASHES - OTHER GYNECOLOGIC METASTASES

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Figure 55
Peritoneal effusion: Papillary serous carcinoma of the endometrium. 20X
Figure 55
 Peritoneal effusion: Papillary serous carcinoma of the endometrium. 20X
Image 3
Figure 56
Peritoneal effusion: Papillary serous carcinoma of the endometrium. 40X
Figure 56
 Peritoneal effusion: Papillary serous carcinoma of the endometrium. 40X
Figures 55-56:
Peritoneal effusion, papillary serous carcinoma of the endometrium. Malignant cells clustered around psammoma bodies.

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Figure 57
 Peritoneal effusion: Endometrial adenocarcinoma. Low power photomicrograph shows two separate cell populations. Note the flat sheet at the lower left of uniform, benign cells, many dyshesive tumor cells at lower right, with a large cohesive fragment of tumor cells at upper left. 20X
Figure 57
 Peritoneal effusion: Endometrial adenocarcinoma. Low power photomicrograph shows two separate cell populations. Note the flat sheet at the lower left of uniform, benign cells, many dyshesive tumor cells at lower right, with a large cohesive fragment of tumor cells at upper left. 20X
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Figure 58
Peritoneal effusion: Endometrial adenocarcinoma. Malignant cells with features of adenocarcinoma including a mitotic figure, prominent nucleoli, vacuolated cytoplasm and eccentric nuclei. 60X
Figure 58
 Peritoneal effusion: Endometrial adenocarcinoma. Malignant cells with features of adenocarcinoma including a mitotic figure, prominent nucleoli, vacuolated cytoplasm and eccentric nuclei. 60X
Image 3
Figure 59
Pleural effusion: Endometrial adenocarcinoma. 20X
Figure 59
 Pleural effusion: Endometrial adenocarcinoma. 20X
Image 3
Figure 60
Pleural effusion: Endometrial adenocarcinoma. 40X
Figure 60
 Pleural effusion: Endometrial adenocarcinoma. 40X
Figures 59-60:
Pleural effusion: Endometrial adenocarcinoma. This pleural effusion contains large clusters of malignant cells. Note increased cell size relative to lymphocytes and mesothelial cells in the background. A discontinuous population is one characteristic of malignancy in body effusions

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Figure 61
Pleural effusion: Papillary adenocarcinoma of peritoneal surface. The origin of this tumor is extra-ovarian carcinoma or carcinoma of Müellerian origin. Note distinction from benign cells. 10X
Figure 61
 Pleural effusion: Papillary adenocarcinoma of peritoneal surface. The origin of this tumor is extra-ovarian carcinoma or carcinoma of Müellerian origin. Note distinction from benign cells. 10X
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Figure 62
Pleural effusion: Adenocarcinoma. Papillary clusters of malignant cells. 20X
Figure 62
 Pleural effusion: Adenocarcinoma. Papillary clusters of malignant cells. 20X
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Figure 63
Pleural effusion cell block: Adenocarcinoma. A cell block further highlights the distinct malignant cell population and allows for immunohistochemical analysis of cell markers for differentiation and prognosis. 10X
Figure 63
 Pleural effusion cell block: Adenocarcinoma. A cell block further highlights the distinct malignant cell population and allows for immunohistochemical analysis of cell markers for differentiation and prognosis. 10X
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Figure 64
Pelvic wash: Undifferentiated large cell carcinoma of the cervix. Cytology shows rounded clusters of malignant cells. 60X
Figure 64
 Pelvic wash: Undifferentiated large cell carcinoma of the cervix. Cytology shows rounded clusters of malignant cells. 60X
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Figure 65
Pelvic wash: Carcinoma of the cervix. Magnified view shows vacuolated cytoplasm, prominent nucleoli, and powdery chromatin pattern suggesting an adenocarcinoma. 60X
Figure 65
 Pelvic wash: Carcinoma of the cervix. Magnified view shows vacuolated cytoplasm, prominent nucleoli, and powdery chromatin pattern suggesting an adenocarcinoma. 60X
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Figure 66
Pelvic wash: Carcinosarcoma. 20X
Figure 66
 Pelvic wash: Carcinosarcoma. 20X
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Figure 67
Pelvic wash: Carcinosarcoma. 60X
Figure 67
 Pelvic wash: Carcinosarcoma. 60X
Figures 66-67:
Pelvic wash: Carcinosarcoma. Clusters of high-grade malignant cells. Look for both malignant epithelial and malignant stromal cell components.

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Figure 68
Peritoneal effusion: Fallopian tube adenocarcinoma. 20X
Figure 68
 Peritoneal effusion: Fallopian tube adenocarcinoma. 20X
Image 3
Figure 69
Peritoneal effusion: Fallopian tube adenocarcinoma. 60X
Figure 69
 Peritoneal effusion: Fallopian tube adenocarcinoma. 60X
Figures 68-69:
Peritoneal effusion: Fallopian tube adenocarcinoma. A rare, highly malignant tumor. Consider this diagnosis when peritoneal effusion presents without evidence of ovarian or endometrial pathology. Note the prominent cytoplasmic vacuoles.

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